Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.5.2 extracted from

  • Fueller, F.; Kubatzky, K.F.
    The small GTPase RhoH is an atypical regulator of haematopoietic cells (2008), Cell Commun. Signal., 6, 6-6.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
additional information some of the amino acids that are crucial for GTPase activity are mutated in RhoH so that the protein is a GTPase-deficient, so-called atypical Rho GTPase. Other mechanisms of regulating RhoH activity include regulation at the mRNA level and tyrosine phosphorylation of the protein's unique ITAM-like motif. The C-terminal CaaX box of RhoH is mainly a target for farnesyl-transferase but can also be modified by geranylgeranyltransferase. Isoprenylation of RhoH and changes in subcellular localisation may be an additional factor to fine-tune signalling Mus musculus
additional information some of the amino acids that are crucial for GTPase activity are mutated in RhoH so that the protein is a GTPase-deficient, so-called atypical Rho GTPase. Other mechanisms of regulating RhoH activity include regulation at the mRNA level and tyrosine phosphorylation of the protein's unique ITAM-like motif. The C-terminal CaaX box of RhoH is mainly a target for farnesyl-transferase but can also be modified by geranylgeranyltransferase. Isoprenylation of RhoH and changes in subcellular localisation may be an additional factor to fine-tune signalling Homo sapiens

Application

Application Comment Organism
medicine neither the overall survival nor the disease-free survival rate in diffuse large B-cell lymphoma can be linked to hypermutation of the RHOH gene Mus musculus
medicine neither the overall survival nor the disease-free survival rate in diffuse large B-cell lymphoma can be linked to hypermutation of the RHOH gene Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
membrane only the membrane-localised form of RhoH is able to downregulate Rac1 efficiently Mus musculus 16020
-
membrane only the membrane-localised form of RhoH is able to downregulate Rac1 efficiently Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity ?
-
 ?
additional information Homo sapiens RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity ?
-
 ?
additional information Mus musculus the small GTPase RhoH is an atypical regulator of haematopoietic cells ?
-
 ?
additional information Homo sapiens the small GTPase RhoH is an atypical regulator of haematopoietic cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15669
-
-
Mus musculus Q9D3G9
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the CKIF motif in human RhoH is a target for the in vitro modification by farnesyl-transferase and geranylgeranyl-transferase Homo sapiens
additional information the CKIF motif in mouse RhoH is a target for the in vitro modification by farnesyl-transferase and geranylgeranyl-transferase Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell RhoH is specifically expressed in hematopoietic cells Mus musculus
-
hematopoietic cell RhoH is specifically expressed in hematopoietic cells Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
additional information RhoH is underexpressed in hairy cell leukaemia and acute myeloid leukaemia cells Homo sapiens
-
NIH-3T3 cell
-
 Mus musculus
-
T-lymphocyte RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling Mus musculus
-
T-lymphocyte RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity Mus musculus ?
-
 ?
additional information RhoH inhibits IkappaB degradation and acts as a specific negative regulator for Rac and RhoA-induced p38 activity Homo sapiens ?
-
 ?
additional information the small GTPase RhoH is an atypical regulator of haematopoietic cells Mus musculus ?
-
 ?
additional information the small GTPase RhoH is an atypical regulator of haematopoietic cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
RhoH initially named translation three four, RhoH is a GTPase-deficient so-called atypical Rho GTPase, RhoH is only found in vertebrates Mus musculus
RhoH initially named translation three four, RhoH is a GTPase-deficient so-called atypical Rho GTPase, RhoH is only found in vertebrates Homo sapiens