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Literature summary for 3.6.5.2 extracted from
- Spatial and temporal coordination of mitosis by Ran GTPase (2008), Nat. Rev. Mol. Cell Biol., 9, 464-477.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Mus musculus | small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions | GDP + phosphate | - |
? |  |
| GTP + H2O | Homo sapiens | small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions | GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions | Mus musculus | GDP + phosphate | - |
? | |
| GTP + H2O | small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran has important roles during mitosis, when the nucleus is reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions | Homo sapiens | GDP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| small nuclear GTPase Ran | - |
Mus musculus |
| small nuclear GTPase Ran | - |
Homo sapiens |
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