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Literature summary for 3.6.5.2 extracted from

  • Bourne, H.R.; Sanders, D.A.; McCormick, F.
    The GTPase superfamily: conserved structure and molecular mechanism (1991), Nature, 349, 117-127.
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
GTPase activating protein GAP stimulating intrinsic GTPase acitivity Escherichia coli
GTPase activating protein GAP stimulating intrinsic GTPase acitivity Homo sapiens
GTPase activating protein GAP stimulating intrinsic GTPase acitivity Saccharomyces cerevisiae
GTPase activating protein GAP stimulating intrinsic GTPase acitivity Oryctolagus cuniculus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Escherichia coli
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ coordinated to oxygens of beta- and gamma-phosphates of GTP, essential for GTP hydrolysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Escherichia coli unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off GDP + phosphate
-
 ir
GTP + H2O Homo sapiens unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off GDP + phosphate
-
 ir
GTP + H2O Saccharomyces cerevisiae unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off GDP + phosphate
-
 ir
GTP + H2O Oryctolagus cuniculus unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off GDP + phosphate
-
 ir
GTP + H2O Escherichia coli EF-Tu unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off GDP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 EF-Tu
-
Escherichia coli EF-Tu
-
 EF-Tu
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
 elF-2
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off Escherichia coli GDP + phosphate
-
 ir
GTP + H2O unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off Homo sapiens GDP + phosphate
-
 ir
GTP + H2O unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off Saccharomyces cerevisiae GDP + phosphate
-
 ir
GTP + H2O unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off Oryctolagus cuniculus GDP + phosphate
-
 ir
GTP + H2O unidirectional cycle in which exchange of GDP for GTP turns on a switch and GTP hydrolysis turns it off Escherichia coli EF-Tu GDP + phosphate
-
 ir

Synonyms

Synonyms Comment Organism
EF-Tu
-
 Escherichia coli
elF-2
-
 Oryctolagus cuniculus
p21 ras
-
 Homo sapiens
RAS1
-
 Saccharomyces cerevisiae
RAS2
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0005
-
 GTP quite low, increased GTP hydrolysis by action of guanine nucleotide release proteins, promoting replacement of bound GDP by GTP Homo sapiens