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Literature summary for 3.6.5.2 extracted from
- Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1) (1998), J. Biol. Chem., 273, 2553-2560.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | identification of an N-terminal GAP domain | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzymes, affinity chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
ir | |
| guanosine 5'-O-(3-thiotriphosphate) + H2O | no detectable hydrolysis of GTP at the ARF domain p3, 35-40% of the GTP bound to ARD1 domain p8 hydrolyzed in 1 h at room temperature | Homo sapiens | guanosine 5'-O-diphosphate + thiophosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ARD1 | ARF subfamily, stimulates cholera toxin ADP ribosyltransferase, involved in vesicular trafficking, key regulator for interaction of non-clathrin coat proteins with Golgi stacks and clathrin adaptor particles with the trans-Golgi network | Homo sapiens |
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