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Literature summary for 3.6.5.2 extracted from

  • Haberland, J.; Gerke, V.
    Conserved charged residues in the leucin-rich repeat domain of the Ran GTPase activating protein are required for Ran binding and GTPase activation (1999), Biochem. J., 343, 653-662.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
GTPase activating protein GAP complex formation with Ran, stimulates intrinsic GTPase activity Homo sapiens
GTPase activating protein GAP complex formation with Ran, stimulates intrinsic GTPase activity Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear pore complex RanGTPase activating protein-Ran complex, stimulation of GTP hydrolysis, terminating export Saccharomyces cerevisiae
-
-
nuclear pore complex cytosolic surface Saccharomyces cerevisiae
-
-
nucleus
-
 Saccharomyces cerevisiae 5634
-
nucleus RanGTP form, mediates termination of import and initiation of export Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ir
GTP + H2O Saccharomyces cerevisiae
-
 GDP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzymes, affinity chromatography Homo sapiens
recombinant enzymes, affinity chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ir
GTP + H2O
-
 Saccharomyces cerevisiae GDP + phosphate
-
 ir

Synonyms

Synonyms Comment Organism
Ran Ras-related, participating in nucleocytoplasmatic transport Homo sapiens