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Literature summary for 3.6.5.1 extracted from

  • Pandey, S.
    Heterotrimeric G-protein regulatory circuits in plants conserved and novel mechanisms (2017), Plant Signal. Behav., 12, e1325983 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.1

Activating Compound

Activating Compound Comment Organism Structure
additional information GTPase activity accelerating proteins (GAPs) are required to increase the rate of deactivation, and to maintain the kinetics of G-protein cycle Arabidopsis thaliana
phospholipase Dalpha1 PLDalpha1, a GTPase activity accelerating protein (GAP). Phosphatidic acid (PA), a key product of PLDalpha1 activity, can bind with and modulate the GAP activity of RGS1, another GAP. Abscisic acid treatment likely results in the activation of PLDalpha1, which leads to PA production Arabidopsis thaliana
regulator of G-protein signaling 1 RGS1, a GTPase activity accelerating protein (GAP). Phosphatidic acid (PA), a key product of PLDalpha1 activity, can bind with and modulate the GAP activity of RGS1. PA binding to RGS1 provides a molecular link between lipid- and G-protein mediated signaling. The RGS1K259E mutant is active and functional, but shows reduced binding of PA Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Arabidopsis thaliana
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Arabidopsis thaliana GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Galpha protein
-
 Arabidopsis thaliana
GPA1
-
 Arabidopsis thaliana
heterotrimeric G-protein
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution the core G-protein components and their activation/deactivation chemistries are broadly conserved throughout the eukaryotic evolution, while their regulatory mechanisms seem to have been rewired in plants to meet specific needs. Plants such as Arabidopsis, which have a limited number of G-protein components and their regulators, offer a unique opportunity to dissect the mechanistic details of distinct signaling pathways Arabidopsis thaliana
metabolism efficient activation and deactivation of Galpha protein is critical for the regulation of heterotrimeric G-protein mediated signaling pathways. Plants such as Arabidopsis, which have a limited number of G-protein components and their regulators, offer a unique opportunity to dissect the mechanistic details of distinct signaling pathways. Interaction occurs between the regulator of G-protein signaling 1 (RGS1) and phospholipase Dalpha1 (PLDalpha1), which are two of the GTPase activity accelerating proteins (GAPs) of the Arabidopsis Galpha protein, GPA1. Phosphatidic acid (PA), a key product of phospholipase Dalpha1 (PLDalpha1) activity, can bind with and modulate the GAP activity of RGS1, uncovering a molecular link between lipid and G-protein signaling and its role in providing the specificity of response regulation. Heterotrimeric G-protein signaling mechanisms and regulation, G-protein signaling model, overview Arabidopsis thaliana
additional information the core G-protein heterotrimeric complex consists of one Glphaa, one Gbeta, and one Ggamma protein. The protein complex switches between the inactive and active states depending on the nucleotide- bound form of Galpha. During resting phase, Galpha is GDP-bound and remains associated with the Gbetagamma proteins in a trimeric conformation (GDP-Galphabetagamma). Activation occurs due to the signal-dependent exchange of GDP on Galpha for GTP. GTP-bound Galpha dissociates from the Gbetagamma dimer and both GTP-Galpha and Gbetagamma can interact with downstream effectors to transduce the signal. Deactivation occurs via the inherent GTPase activity of Galpha, which causes hydrolysis of bound GTP, to produce its GDP-bound form. GDP-Galpha reassociates with Gbetagamma generating the trimeric complex, ready to be activated for the next round of signaling Arabidopsis thaliana
physiological function efficient activation and deactivation of Galpha protein is critical for the regulation of heterotrimeric G-protein mediated signaling pathways. Heterotrimeric GTP-binding proteins (G-proteins) are key regulators of a multitude of signaling pathways in all eukaryotes. In plants, G-proteins are currently a focus of intense research due to their involvement in modulation of many agronomically important traits such as abscisic acid-dependent signaling and stress responses, plant defense responses, seed yield, organ size, symbiosis and nitrogen use efficiency. Heterotrimeric G-protein signaling mechanisms and regulation, overview. GTPase activity accelerating proteins (GAPs) are required to increase the rate of deactivation, and to maintain the kinetics of G-protein cycle. Direct role of ABA-dependent phosphatidic acid production in the regulation of G-protein cycle during seed germination and primary root growth Arabidopsis thaliana