Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the levels of Ric-8A are critical during migration and affect the localization of polarity markers and the subcellular localization of GTPase activity | Xenopus tropicalis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Xenopus tropicalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Xenopus tropicalis | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus tropicalis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Xenopus tropicalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Xenopus tropicalis | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GTPase | - |
Xenopus tropicalis |
heterotrimeric G-protein | - |
Xenopus tropicalis |
General Information | Comment | Organism |
---|---|---|
metabolism | Ric-8A controls cell polarization during migration probably through Galpha subunit regulation. Ric-8A by its two function as GEF and chaperone may regulate cell polarity by regulating the localization of proteins, such as Galpha-GDP, GPR1/GPR2 and Lin-5, during asymmetric cell division. Therefore in the context of migration it may also interact with a Galpha subunit, and its downstream effectors regulating aPKC and Par3 localization, then under Ric-8A morphant condition, the localization of these proteins is abnormal. Because GTPases regulate each other, any misregulation in one can result in abnormal regulation in the others | Xenopus tropicalis |
physiological function | heterotrimeric G proteins control cell migration in a variety of cellular types, also during embryogenesis. Four of the five Galpha subunit family members (Galpha12/13, Galphai/o, Galpha/11, and Galphas) are related to migration, activating different signaling cascades and promoting actin cytoskeleton reorganization through the regulation of small GTPase family proteins. The canonical cycle of heterotrimeric G protein signaling begins when a ligand binds to its receptor, which acts as a GEF and induces the activation of Galpha subunits and release from Gbetagamma by the exchange of GDP by GTP. In addition, some GEFs are ligand-independent, such as Ric-8, which accelerates the exchange of GDP for GTP on the Galpha subunit, thereby maintaining an active signaling state. The levels of Ric-8A are critical during migration and affect the localization of polarity markers and the subcellular localization of GTPase activity, suggesting that Ric-8A, probably through heterotrimeric G-protein signaling, regulates cell polarity during CNC migration, overview | Xenopus tropicalis |