Literature summary for 3.6.5.1 extracted from

Kerov, V.; Chen, D.; Moussaif, M.; Chen, Y.J.; Chen, C.K.; Artemyev, N.O.
Transducin activation state controls its light-dependent translocation in rod photoreceptors (2005), J. Biol. Chem., 280, 41069-41076.

Search for more literature for 3.6.5.1

Activating Compound

Activating Compound	Comment	Organism	Structure
RGS9	-	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
pBRH Gtalpha transgenic construct containing the mouse Gtalpha genomic sequence flanked by the mouse opsin promoter fragment and the polyadenylation signal, EE-tagged	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
GtalphaQ200L	GTPase-deficient mutant	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
photoreceptor inner segment	light-dependent localizations of the transducin-alpha subunit Gtalpha	Mus musculus	1917	-
photoreceptor outer segment	light-dependent localizations of the transducin-alpha subunit Gtalpha	Mus musculus	1750	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Mus musculus	-	GDP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
outer nuclear layer	light-dependent localizations of the transducin-alpha subunit Gtalpha	Mus musculus	-
outer plexiform layer	light-dependent localizations of the transducin-alpha subunit Gtalpha	Mus musculus	-
retinal rod	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Mus musculus	GDP + phosphate	-	?

Subunits

Subunits	Comment	Organism
heterotrimer	Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer	Mus musculus

Synonyms

Synonyms	Comment	Organism
GTP phosphohydrolase	-	Mus musculus
heterotrimeric G-protein GTPase	-	Mus musculus
transducin	-	Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0018	-	GTP	GtalphaQ200L	Mus musculus
0.019	-	GTP	Gtalpha	Mus musculus

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Release 2023.1 (January 2023)