Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.5.1 extracted from

  • Siderovski, D.P.; Willard, F.S.
    The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits (2005), Int. J. Biol. Sci., 1, 51-66.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Axin protein member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
Axin2 protein member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
D-AKAP2 protein
-
Homo sapiens
EGL-10 protein egg-laying defective protein 10 Caenorhabditis elegans
FlbA protein
-
Aspergillus nidulans
GRK1 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
GRK2 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
GRK3 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
GRK4 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
GRK5 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
GRK6 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
GRK7 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
LARG protein member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
p115-RhoGEF protein member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
PDZ-RhoGEF protein member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS1 protein human B-lymphocyte, member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS10 protein member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS11 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS12 protein member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS13 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS14 protein member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS16 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS17 protein member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS18 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS19 protein member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS2 protein human T-lymphocyte, member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS20 protein member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS21 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS22 protein
-
Homo sapiens
RGS3 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS4 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS5 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS6 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS7 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS8 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
RGS9 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
SNX13 protein member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
SNX14 protein member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
SNX25 protein member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
Sst2 protein Sst2: supersensitivity to pheromone-2 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens
-
GDP + phosphate
-
?
GTP + H2O Saccharomyces cerevisiae
-
GDP + phosphate
-
?
GTP + H2O Aspergillus nidulans
-
GDP + phosphate
-
?
GTP + H2O Caenorhabditis elegans
-
GDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
Aspergillus Emericella nidulans
-
Caenorhabditis elegans
-
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Homo sapiens GDP + phosphate
-
?
GTP + H2O
-
Saccharomyces cerevisiae GDP + phosphate
-
?
GTP + H2O
-
Aspergillus nidulans GDP + phosphate
-
?
GTP + H2O
-
Caenorhabditis elegans GDP + phosphate
-
?

Subunits

Subunits Comment Organism
heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Homo sapiens
heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Saccharomyces cerevisiae
heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Aspergillus nidulans
heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
GTP phosphohydrolase
-
Homo sapiens
GTP phosphohydrolase
-
Saccharomyces cerevisiae
GTP phosphohydrolase
-
Aspergillus nidulans
GTP phosphohydrolase
-
Caenorhabditis elegans
heterotrimeric G-protein GTPase
-
Homo sapiens
heterotrimeric G-protein GTPase
-
Saccharomyces cerevisiae
heterotrimeric G-protein GTPase
-
Aspergillus nidulans
heterotrimeric G-protein GTPase
-
Caenorhabditis elegans