Literature summary for 3.6.4.6 extracted from

Xia, Y.; Liu, N.; Xie, X.; Bi, G.; Ba, H.; Li, L.; Zhang, J.; Deng, X.; Yao, Y.; Tang, Z.; Yin, B.; Wang, J.; Jiang, K.; Li, Z.; Choi, Y.; Gong, F.; Cheng, X.; OShea, J.J.; Chae, J.J.; Laurence, A.; Yang, X.P.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion (2019), Autophagy, 15, 960-975 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O	Mus musculus	-	ADP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow-derived macrophage	high expression	Mus musculus	-
mast cell	modest expression	Mus musculus	-
additional information	not expressed in lymphoid cells	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	Mus musculus	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
ATP6V0D1	subunit	Mus musculus
ATP6V0D2	subunit	Mus musculus
V-ATPase	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	thr expression of subunit ATP6V0D2 is most inhibited by the addition of lipopolysaccharide	down

General Information

General Information	Comment	Organism
malfunction	subunit Atp6v0d2-deficient macrophages have augmented mitochondrial damage, enhanced inflammasome activation and reduced clearance of Salmonella typhimurium	Mus musculus
physiological function	subunit ATP6V0D2 is a key component of macrophage-specific autophagosome-lysosome fusion machinery maintaining macrophage organelle homeostasis and, in turn, limiting both inflammation and bacterial infection. The enzyme subunit Atp6v0d2 inhibits inflammasome-dependent colitis. Subunit ATP6V0D1 but not ATP6V0D2 is required for lysosome acidification and maturation in macrophages. Subunit ATP6V0D2, but not ATP6V0D1, forms a complex with VAMP8 and STX17, and is required for the optimal stabilization of this complex in activated macrophages	Mus musculus

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Release 2023.1 (January 2023)