Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Mus musculus | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow-derived macrophage | high expression | Mus musculus | - |
mast cell | modest expression | Mus musculus | - |
additional information | not expressed in lymphoid cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Mus musculus | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP6V0D1 | subunit | Mus musculus |
ATP6V0D2 | subunit | Mus musculus |
V-ATPase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | thr expression of subunit ATP6V0D2 is most inhibited by the addition of lipopolysaccharide | down |
General Information | Comment | Organism |
---|---|---|
malfunction | subunit Atp6v0d2-deficient macrophages have augmented mitochondrial damage, enhanced inflammasome activation and reduced clearance of Salmonella typhimurium | Mus musculus |
physiological function | subunit ATP6V0D2 is a key component of macrophage-specific autophagosome-lysosome fusion machinery maintaining macrophage organelle homeostasis and, in turn, limiting both inflammation and bacterial infection. The enzyme subunit Atp6v0d2 inhibits inflammasome-dependent colitis. Subunit ATP6V0D1 but not ATP6V0D2 is required for lysosome acidification and maturation in macrophages. Subunit ATP6V0D2, but not ATP6V0D1, forms a complex with VAMP8 and STX17, and is required for the optimal stabilization of this complex in activated macrophages | Mus musculus |