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Literature summary for 3.6.4.6 extracted from

  • Wang, F.; Yang, Y.; Wang, Z.; Zhou, J.; Fan, B.; Chen, Z.
    A critical role of Lyst-interacting protein5, a positive regulator of multivesicular body biogenesis, in plant responses to heat and salt stresses (2015), Plant Physiol., 169, 497-511.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.6

Activating Compound

Activating Compound Comment Organism Structure
LIP5F388A a weak SKD1 interactor, complements the lip5 mutant for heat and salt stress tolerance, most likely due to its overexpression driven by the strong CaMV 35S promoter in the transgenic plants Arabidopsis thaliana
Lyst-interacting protein5 LIP5, interacts strongly with enzyme SKD1 and stimulates the ATPase activity of the enzyme by 4 to 5fold. LIP5 is a positive regulator of enzyme SKD1 in multivesicular bodies biogenesis and is a critical target of the mitogen-activated protein kinases MPK3 and MPK6 and plays an important role in the plant immune system. Disruption of LIP5 causes compromised tolerance to both heat and salt stresses. When compared with wild-type plants, lip5 mutants accumulate increased levels of ubiquitinated protein aggregates and NaCl under heat and salt stresses, respectively. LIP5 is regulated by phosphorylation, overview. Mutation of MPK phosphorylation sites in LIP5 does not affect its interaction with SKD1 but reduces its stability and, as a result, compromises its ability to complement the basal resistance of the lip5 mutants Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Arabidopsis thaliana
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9ZNT0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Arabidopsis thaliana ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
SKD1
-
 Arabidopsis thaliana
Suppressor of K+ Transport Growth Defect1
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution enzyme SKD1 belongs to the AAA ATPase family Arabidopsis thaliana
physiological function enzyme SKD1 is involved in multivesicular bodies biogenesis, the LIP5-regulated multivesicular bodies biogenesis, MVB, pathway also plays a critical role in plant responses to abiotic stresses. The critical role of LIP5 in plant tolerance to abiotic stresses is dependent on its ability to interact with the enzyme SKD1 Arabidopsis thaliana