Literature summary for 3.6.4.6 extracted from

Pye, V.E.; Dreveny, I.; Briggs, L.C.; Sands, C.; Beuron, F.; Zhang, X.; Freemont, P.S.
Going through the motions: The ATPase cycle of p97 (2006), J. Struct. Biol., 156, 12-28.

Search for more literature for 3.6.4.6

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activity is dependent upon hexamerisation	Drosophila melanogaster
additional information	activity is dependent upon hexamerisation	Saccharomyces cerevisiae
additional information	activity is dependent upon hexamerisation	Arabidopsis thaliana
additional information	activity is dependent upon hexamerisation	Archaea
additional information	activity is dependent upon hexamerisation	protozoa

Application

Application	Comment	Organism
medicine	dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases	Drosophila melanogaster
medicine	dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases	Saccharomyces cerevisiae
medicine	dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases	Arabidopsis thaliana
medicine	dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases	Archaea
medicine	dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases	protozoa

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Drosophila melanogaster
-	Saccharomyces cerevisiae
-	Arabidopsis thaliana
-	Archaea
-	protozoa

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Drosophila melanogaster
Mg2+	-	Saccharomyces cerevisiae
Mg2+	-	Arabidopsis thaliana
Mg2+	-	Archaea
Mg2+	-	protozoa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O	Drosophila melanogaster	-	ADP + phosphate	-	ir
ATP + H2O	Saccharomyces cerevisiae	-	ADP + phosphate	-	ir
ATP + H2O	Arabidopsis thaliana	-	ADP + phosphate	-	ir
ATP + H2O	Archaea	-	ADP + phosphate	-	ir
ATP + H2O	protozoa	-	ADP + phosphate	-	ir

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-
Archaea	-	-	-
Drosophila melanogaster	-	-	-
protozoa	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	Drosophila melanogaster	ADP + phosphate	-	ir
ATP + H2O	-	Saccharomyces cerevisiae	ADP + phosphate	-	ir
ATP + H2O	-	Arabidopsis thaliana	ADP + phosphate	-	ir
ATP + H2O	-	Archaea	ADP + phosphate	-	ir
ATP + H2O	-	protozoa	ADP + phosphate	-	ir

Subunits

Subunits	Comment	Organism
hexamer	-	Drosophila melanogaster
hexamer	-	Saccharomyces cerevisiae
hexamer	-	Arabidopsis thaliana
hexamer	-	Archaea
hexamer	-	protozoa

Synonyms

Synonyms	Comment	Organism
Cdc48	-	Drosophila melanogaster
Cdc48	-	Saccharomyces cerevisiae
Cdc48	-	Arabidopsis thaliana
Cdc48	-	Archaea
Cdc48	-	protozoa
p97	-	Drosophila melanogaster
p97	-	Saccharomyces cerevisiae
p97	-	Arabidopsis thaliana
p97	-	Archaea
p97	-	protozoa
VCP	-	Drosophila melanogaster
VCP	-	Saccharomyces cerevisiae
VCP	-	Arabidopsis thaliana
VCP	-	Archaea
VCP	-	protozoa

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Release 2023.1 (January 2023)