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Literature summary for 3.6.4.6 extracted from

  • Hanley, J.G.
    NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2 (2007), J. Neurochem., 101, 1644-1650.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
His6-NSF for expression in Escherichia coli BL21 cells Mammalia

Protein Variants

Protein Variants Comment Organism
D100A mutant to study the Ca2+ sensitivity of the interaction between NSF and the glutamate receptor subunit 2 of AMPAR Mammalia
D142A mutant to study the Ca2+ sensitivity of the interaction between NSF and the glutamate receptor subunit 2 of AMPAR Mammalia
E153A mutant to study the Ca2+ sensitivity of the interaction between NSF and the glutamate receptor subunit 2 of AMPAR Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse
-
Mammalia 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ NSF is a Ca2+-binding protein, GluR2-NSF interactions are inhibited by the presence of 15 micromol/l Ca2+ Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Mammalia
-
ADP + phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Mammalia ADP + phosphate
-
ir

Synonyms

Synonyms Comment Organism
N-ethylmaleimide-sensitive fusion protein
-
Mammalia
NSF
-
Mammalia