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Literature summary for 3.6.4.6 extracted from

  • Babst, M.; Wendland, B.; Estepa, E.J.; Emr, S.D.
    The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function (1998), EMBO J., 17, 2982-2993.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
VPS24 gene cloned from a yeast genomic library Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Saccharomyces cerevisiae 5768
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
predicted from amino acid sequence Saccharomyces cerevisiae
85000
-
mutant Vps4pdeltaCC/E233Q, gel filtration Saccharomyces cerevisiae
95000
-
Vps4p, gel filtration Saccharomyces cerevisiae
400000
-
mutant Vps4pdeltaCC/E233Q, gel filtration Saccharomyces cerevisiae
440000
-
mutant Vps4pE233Q, gel filtration Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Saccharomyces cerevisiae
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Saccharomyces cerevisiae ADP + phosphate
-
?

Subunits

Subunits Comment Organism
decamer mutants Vps4pE233Q and Vps4pdeltaCC/E233Q, SDS-PAGE Saccharomyces cerevisiae
dimer SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Cdc48p
-
Saccharomyces cerevisiae
NSF protein
-
Saccharomyces cerevisiae
SEC18 gene product
-
Saccharomyces cerevisiae
Vps4p
-
Saccharomyces cerevisiae
Vps4p AAA ATPase
-
Saccharomyces cerevisiae