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Literature summary for 3.6.4.13 extracted from
- The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export (2012), J. Cell. Biochem., 113, 985-996.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinantly expressed as a His-tagged fusion protein | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | DDX3 and DDX5 both co-localize in the cytoplasm | Homo sapiens | 5737 | - |
| nucleus | DDX5 is shutteld into the nucleus by DDX3 | Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | DEAD-Box RNA Helicase DDX3 interacts with DDX5. The protein-protein interaction is increased in the G2/M phase | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P17844 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation at serine/threonine residues of both DDX3 and DDX5 affect the protein-protein interaction. During the G2/M phase, phosphorylation of DDX3 is decreased, whereas, the phosphorylation of DDX5 is, compared with the G1/S phase | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using Ni-NTA chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | DEAD-Box RNA Helicase DDX3 interacts with DDX5. The protein-protein interaction is increased in the G2/M phase | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDX3 | - |
Homo sapiens |
| DDX5 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | DDX3 knockdown blocks the shuttling of DDX5 to the nucleus | Homo sapiens |
| metabolism | UV cross-linking experiments show that both RNA helicase proteins are involved in mRNP metabolism and that DDX3 affects the shuttling of DDX5 to the nucleus | Homo sapiens |
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