Protein Variants | Comment | Organism |
---|---|---|
C63A | the ATPase activity displayed by the unmodified ATPase domain Kar2 is fully maintained when Cys63 is replaced with Ala | Saccharomyces cerevisiae |
C63E | the mutant shows limited ATPase activity | Saccharomyces cerevisiae |
C63F | the mutation leads to loss of ATPase activity. The mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 | Saccharomyces cerevisiae |
C63H | the mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 | Saccharomyces cerevisiae |
C63N | the mutant shows limited ATPase activity | Saccharomyces cerevisiae |
C63P | the mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 | Saccharomyces cerevisiae |
C63V | the ATPase activity displayed by the unmodified ATPase domain Kar2 is fully maintained when Cys63 is replaced with Val | Saccharomyces cerevisiae |
C63W | the mutation leads to loss of ATPase activity. The mutation leads to loss of ATPase activity. The mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 | Saccharomyces cerevisiae |
C63Y | the mutation leads to loss of ATPase activity. The mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Saccharomyces cerevisiae | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 75000, SDS-PAGE | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
ATP-dependent foldase | - |
Saccharomyces cerevisiae |
BiP | - |
Saccharomyces cerevisiae |
endoplasmic reticulum chaperone | - |
Saccharomyces cerevisiae |
Kar2 | ATPase domain of BiP | Saccharomyces cerevisiae |