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Literature summary for 3.6.4.10 extracted from
- Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity (2006), J. Biol. Chem., 281, 5468-5475.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Bacillus subtilis ClpC adaptor protein MecA | the refolding activity of SyClpC is enhanced 3fold in presence of Bacillus subtilis ClpC adaptor protein MecA | Synechococcus elongatus | |
| L-cysteine | stimulates 2fold | Synechococcus elongatus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Escherichia coli-based overexpression system | Synechococcus elongatus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Synechococcus elongatus | - |
ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Synechococcus elongatus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant | Synechococcus elongatus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Synechococcus elongatus | ADP + phosphate | - |
? | |
| ATP + H2O | SyClpC displays intrinsic chaperone activity in vitro, first by preventing aggregation of unfolded polypeptides and second by resolubilizing and refolding aggregated proteins into their native structures. The refolding activity of SyClpC is enhanced 3fold in presence of Bacillus subtilis ClpC adaptor protein MecA | Synechococcus elongatus | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SyClpC | - |
Synechococcus elongatus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 45 | ATP hydrolysis | Synechococcus elongatus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 34 | 47 | about 60% of maximal activity at 34°C and at 47°C | Synechococcus elongatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | ATP hydrolysis | Synechococcus elongatus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.5 | pH 6.5: about 50% of maximal activity, pH 8.5: about 75% of maximal activity | Synechococcus elongatus |
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Release 2023.1 (January 2023)
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