Application | Comment | Organism |
---|---|---|
medicine | Hsp90 is a molecular target for cancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17-(allylamino)-17-demethoxygeldanamycin | - |
Homo sapiens | |
17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride | - |
Homo sapiens | |
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride | - |
Homo sapiens | |
cisplatin | - |
Homo sapiens | |
CNF1010 | - |
Homo sapiens | |
geldanamycin | inhibits hsp90 function in vitro at low micromolar concentrations via the interaction with the N-terminal ATP-binding domain of Hsp90, which results in destabilization of oncogenic client proteins via the proteasomal degradation pathway | Homo sapiens | |
mycograb | - |
Homo sapiens | |
novobiocin | analogs | Homo sapiens | |
radicicol | and oxime drivatives | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Homo sapiens | hsp90 is responsible for controlling the conformation, stability, activation, intracellular disposition, and proteolytic turnover of numerous important proteins that are involved in cell growth differentiation and survival | ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
ATP + H2O | hsp90 is responsible for controlling the conformation, stability, activation, intracellular disposition, and proteolytic turnover of numerous important proteins that are involved in cell growth differentiation and survival | Homo sapiens | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heat shock protein 90 | - |
Homo sapiens |
Hsp90 | - |
Homo sapiens |