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Literature summary for 3.6.4.10 extracted from

  • Chadli, A.; Ladjimi, M.M.; Baulieu, E.E.; Catelli, M.G.
    Heat-induced oligomerization of the molecular chaperone Hsp90 (1999), J. Biol. Chem., 274, 4133-4239.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Nonidet P-40
-
Gallus sp.

Inhibitors

Inhibitors Comment Organism Structure
geldanamycin
-
Escherichia coli
geldanamycin Hsp90 Gallus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Gallus sp. 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mo6+
-
Gallus sp.
V5+
-
Gallus sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
2 * 90000, SDS-PAGE Gallus sp.
184000
-
native PAGE Gallus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Escherichia coli
-
ADP + phosphate
-
?
ATP + H2O Neurospora crassa
-
ADP + phosphate
-
?
ATP + H2O Gallus sp.
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Gallus sp.
-
chicken
-
Neurospora crassa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Neurospora crassa
-
Gallus sp.

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Escherichia coli
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Neurospora crassa
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Gallus sp.

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Gallus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Escherichia coli ADP + phosphate
-
?
ATP + H2O
-
Neurospora crassa ADP + phosphate
-
?
ATP + H2O
-
Gallus sp. ADP + phosphate
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli
dimer 2 * 90000, SDS-PAGE Gallus sp.
oligomer
-
Escherichia coli
oligomer critical temperature of 50°C defines transition from dimers to higher order oligomers Gallus sp.

Synonyms

Synonyms Comment Organism
Hsp90 molecular chaperone
-
Neurospora crassa
Hsp90 molecular chaperone
-
Gallus sp.