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Literature summary for 3.6.4.10 extracted from

  • Brodsky, J.L.
    Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin. Modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions (1999), Biochem. Pharmacol., 57, 877-880.
    View publication on PubMed
Search for more literature for 3.6.4.10

Activating Compound

Activating Compound Comment Organism Structure
15-deoxyspergualin stimulates the ATPase activity of mammalian and yeast cytosolic Hsc70 from 20 to 40%, no effect on HSC70 BiP and DnaJ-stimulated Hsc70 ATPase activity Saccharomyces cerevisiae
15-deoxyspergualin stimulates the ATPase activity of mammalian and yeast cytosolic Hsc70 from 20 to 40%, no effect on HSC70 BiP and DnaJ-stimulated Hsc70 ATPase activity Bos taurus
DnaJ
-
 Rattus norvegicus
DnaJ
-
 Saccharomyces cerevisiae
DnaJ
-
 Bos taurus

Application

Application Comment Organism
medicine development of a potent cytostatic anti-tumor and immunosuppressive agent, 15-deoxyspergualin, a synthetic analogue of the antibiotic spergualin, to prevent rejection in kidney transplant recipients Saccharomyces cerevisiae
medicine development of a potent cytostatic anti-tumor and immunosuppressive agent, 15-deoxyspergualin, a synthetic analogue of the antibiotic spergualin, to prevent rejection in kidney transplant recipients Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Saccharomyces cerevisiae 5829
-
cytosol
-
 Bos taurus 5829
-
endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-
endoplasmic reticulum
-
 Bos taurus 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Rattus norvegicus
-
 ADP + phosphate
-
 ?
ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ?
ATP + H2O Bos taurus
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
 rat
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Rattus norvegicus
a
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Saccharomyces cerevisiae
a
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Rattus norvegicus ADP + phosphate
-
 ?
ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ?
ATP + H2O
-
 Bos taurus ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
eukaryotic Hsc70 ATPase
-
 Saccharomyces cerevisiae
eukaryotic Hsc70 ATPase
-
 Bos taurus