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Literature summary for 3.6.4.10 extracted from
- Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER (1998), Mol. Biol., 9, 3533-3545.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00065 | - |
ATP | mutant K117Q | Saccharomyces cerevisiae |  |
| 0.00072 | - |
ATP | mutant G274D | Saccharomyces cerevisiae | |
| 0.00091 | - |
ATP | mutant G246D | Saccharomyces cerevisiae | |
| 0.002 | - |
ATP | mutant G247D | Saccharomyces cerevisiae | |
| 0.008 | - |
ATP | wild-type | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | hsc70 Ssa1p | Saccharomyces cerevisiae | 5829 | - |
| endoplasmic reticulum | - |
Bos taurus | 5783 | - |
| endoplasmic reticulum | hsc70 BiP | Saccharomyces cerevisiae | 5783 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Cricetulus griseus | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Saccharomyces cerevisiae | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Bos taurus | - |
ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cricetulus griseus | - |
chinese hamster | - |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ssa1p, BiP | Saccharomyces cerevisiae |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Cricetulus griseus | |
| ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Saccharomyces cerevisiae | |
| ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Cricetulus griseus | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Bos taurus | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BiP | - |
Cricetulus griseus |
| BiP | - |
Bos taurus |
| ER lumenal hsc70 BiP | - |
Saccharomyces cerevisiae |
| Hsc70 | - |
Saccharomyces cerevisiae |
| Hsc70 | - |
Bos taurus |
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