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Literature summary for 3.6.4.10 extracted from

  • Panaretou, B.; Prodromou, C.; Roe, S.M.; O'Brien, R.; Ladbury, J.E.; Piper, P.W.; Pearl, L.H.
    ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo (1998), EMBO J., 17, 4829-4836.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.10

Crystallization (Commentary)

Crystallization (Comment) Organism
Hsp90, isoform Hsp82 Saccharomyces cerevisiae
HtpG Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
geldanamycin HtpG Escherichia coli
geldanamycin Hsp90 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 ATP
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Escherichia coli
-
 ADP + phosphate
-
 ?
ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ?
ATP + H2O Saccharomyces cerevisiae PP30
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae PP30
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HtpG Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Escherichia coli
a
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Escherichia coli ADP + phosphate
-
 ?
ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ?
ATP + H2O
-
 Saccharomyces cerevisiae PP30 ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Hsp90 molecular chaperone
-
 Saccharomyces cerevisiae
HtpG
-
 Escherichia coli