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Literature summary for 3.6.1.B18 extracted from

  • Wang, H.; Nair, V.S.; Holland, A.A.; Capolicchio, S.; Jessen, H.J.; Johnson, M.K.; Shears, S.B.
    Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity (2015), Biochemistry, 54, 6462-6474 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.B18

Cloned(Commentary)

Cloned (Comment) Organism
expression in Drosophila melanogaster Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a recombinant Asp1 construct that contains the putative phosphatase domain residues Asp1371-920, is able to dephosphorylate substrates 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate and 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6PFW1 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-
Schizosaccharomyces pombe O74429 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-
Schizosaccharomyces pombe 972 O74429 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-

Reaction

Reaction Comment Organism Reaction ID
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate (2) Schizosaccharomyces pombe
a
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate (1) Schizosaccharomyces pombe
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O
-
 Schizosaccharomyces pombe 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate
-
 ?
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O
-
 Schizosaccharomyces pombe 972 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate
-
 ?
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O
-
 Homo sapiens 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate
-
 ?
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O
-
 Schizosaccharomyces pombe 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
-
 ?
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O
-
 Schizosaccharomyces pombe 972 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
-
 ?
additional information enzyme specifically hydrolyzes the 1-diester phosphate of 1-InsP7 and 1,5-InsP8. No substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Schizosaccharomyces pombe ?
-
 ?
additional information no substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Homo sapiens ?
-
 ?
additional information enzyme specifically hydrolyzes the 1-diester phosphate of 1-InsP7 and 1,5-InsP8. No substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Schizosaccharomyces pombe 972 ?
-
 ?

Synonyms

Synonyms Comment Organism
ASP1
-
 Homo sapiens
ASP1
-
 Schizosaccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
2Fe-2S-center presence of about 2 atoms of iron and acid-labile sulfide per Asp1 molecule. The [2Fe-2S]2+ cluster substantially inhibits the phosphatase activity of Asp1 Schizosaccharomyces pombe