Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.31 | - |
dITP | pH 8.5, 37°C | Homo sapiens | |
0.51 | - |
ITP | pH 8.5, 37°C | Homo sapiens | |
0.57 | - |
xanthosine 5'-triphosphate | pH 8.5, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activity increases sharply up to about 10 mM MgCl2 and reaches a plateau between about 30 and 100 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BY32 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dITP + H2O | at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all | Homo sapiens | dIMP + diphosphate | - |
? | |
ITP + H2O | at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all | Homo sapiens | IMP + diphosphate | - |
? | |
xanthosine 5'-triphosphate + H2O | at the optimal pH of 10.0, the recombinant enzyme hydrolyzes ITP, dITP, and xanthosine 5'-triphosphate to their respective monophosphates whereas activity with other nucleoside triphosphates is low. UTP, (d)CTP, TTP, and (d)ATP are hydrolyzed 10-100fold less than dITP. IDP and IMP are not hydrolyzed at all | Homo sapiens | xanthosine 5'-monophosphate + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
inosine triphosphate pyrophosphatase | - |
Homo sapiens |
ITPase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
360 | - |
dITP | pH 8.5, 37°C | Homo sapiens | |
580 | - |
ITP | pH 8.5, 37°C | Homo sapiens | |
640 | - |
xanthosine 5'-triphosphate | pH 8.5, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
in glycine buffer | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1120 | - |
xanthosine 5'-triphosphate | pH 8.5, 37°C | Homo sapiens | |
1140 | - |
ITP | pH 8.5, 37°C | Homo sapiens | |
1160 | - |
dITP | pH 8.5, 37°C | Homo sapiens |