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Literature summary for 3.6.1.9 extracted from

  • Hou, G.; Cui, Q.
    QM/MM analysis suggests that alkaline phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP superfamil (2012), J. Am. Chem. Soc., 134, 229-246.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.9

Protein Variants

Protein Variants Comment Organism
E322A site-directed mutagenesis Escherichia coli
E322Y site-directed mutagenesis Escherichia coli
R166S site-directed mutagenesis Escherichia coli
R166S/E332Y site-directed mutagenesis Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli
Mg2+ required Xanthomonas citri
Zn2+ effects of Zn2+ binding on enzyme structure, binding structure, overview Escherichia coli
Zn2+ effects of Zn2+ binding on enzyme structure, binding structure, overview Xanthomonas citri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview ?
-
 ?
additional information Xanthomonas citri hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview ?
-
 ?
additional information Xanthomonas citri 306 hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Xanthomonas citri
-
-
-
Xanthomonas citri 306
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview Escherichia coli ?
-
 ?
additional information hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview Xanthomonas citri ?
-
 ?
additional information hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview Xanthomonas citri 306 ?
-
 ?

Subunits

Subunits Comment Organism
More MgNPP- enzyme structure modeling of wild-type and mutant enzymes using the crystal structure, QM/MM calculations and simulation, overview Escherichia coli
More MgNPP- enzyme structure modeling using the crystal structure, QM/MM calculations and simulation, overview Xanthomonas citri

Synonyms

Synonyms Comment Organism
NPP
-
 Escherichia coli
NPP
-
 Xanthomonas citri
nucleotide pyrophosphatase/phosphodiesterase
-
 Escherichia coli
nucleotide pyrophosphatase/phosphodiesterase
-
 Xanthomonas citri

General Information

General Information Comment Organism
additional information active site structure, and MgNPP- enzyme structure modeling of wild-type and mutant enzymes using the crystal structure, QM/MM calculations and simulation, overview. Hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview Escherichia coli
additional information active site structure, and MgNPP- enzyme structure modeling using the crystal structure, QM/MM calculations and simulation, overview. Hydrolysis of MpNPP- in solution, diester hydrolysis reactions with the SCC-DFTBPR based implicit solvent model, overview Xanthomonas citri