Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | enhanced release of FMN at 0.01 mM, increases Vmax | Ovis aries aries |
General Stability | Organism |
---|---|
complete inactivation if repeated freezed and thawed | Ovis aries aries |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-ADP | complete inhibition at 1 mM | Ovis aries aries | |
5'-AMP | sigmoid type of inhibition, phosphate abolishes sigmoidal response | Ovis aries aries | |
ATP | potent inhibition at 0.1 mM | Ovis aries aries | |
CTP | potent inhibition at 0.1 mM | Ovis aries aries | |
diphosphate | complete inhibition above 0.1 mM | Ovis aries aries | |
EDTA | - |
Ovis aries aries | |
FAD+ | 50% inhibition at 1-2 mM | Ovis aries aries | |
FeSO4 | 42% inhibition at 1 mM in the presence of 0.1 mM o-phenanthroline | Ovis aries aries | |
GMP | complete inhibition at 1 mM | Ovis aries aries | |
GSH | 40% inhibition at 1 mM | Ovis aries aries | |
GSSG | 25% inhibition at 1 mM | Ovis aries aries | |
ITP | potent inhibition at 0.1 mM | Ovis aries aries | |
o-phenanthroline | 60-90% inhibition at 0.1 mM, reversal by FeSO4 | Ovis aries aries | |
p-hydroxymercuribenzoate | 60% inhibition at 1 mM, reversal by GSH | Ovis aries aries | |
TTP | 70% inhibition at 1 mM | Ovis aries aries | |
UTP | potent inhibition at 0.1 mM | Ovis aries aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.133 | - |
FAD | with and without phosphate which abolishes negative cooperative interaction | Ovis aries aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
FAD + H2O | Ovis aries aries | - |
FMN + AMP | - |
? | |
NAD+ + H2O | Ovis aries aries | - |
NMN + AMP | - |
? | |
NADP+ + H2O | Ovis aries aries | - |
NMN + adenosine 2',5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries aries | - |
sheep | - |
Purification (Comment) | Organism |
---|---|
partial | Ovis aries aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Ovis aries aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
107 | - |
- |
Ovis aries aries |
Storage Stability | Organism |
---|---|
5°C, 80% of activity remains after 16 h | Ovis aries aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FAD + H2O | - |
Ovis aries aries | FMN + AMP | - |
? | |
NAD+ + H2O | - |
Ovis aries aries | NMN + AMP | - |
? | |
NADP+ + H2O | - |
Ovis aries aries | NMN + adenosine 2',5'-phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | 36 | first optimum | Ovis aries aries |
42 | - |
in the presence of phosphate | Ovis aries aries |
60 | - |
second optimum | Ovis aries aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.7 | - |
- |
Ovis aries aries |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | 2 | FAD+ | - |
Ovis aries aries |