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Literature summary for 3.6.1.9 extracted from

  • Wise, D.J.; Anderson, C.D.; Anderson, B.M.
    Characterization of H. parasuis periplasmic nucleotide pyrophosphatase as a potential target enzyme for inhibition of growth (1997), Vet. Microbiol., 58, 261-276.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5'-ADP competitive inhibition, Ki: 0.0019 mM Glaesserella parasuis
5'-AMP competitive inhibition, Ki: 0.037 mM Glaesserella parasuis
cytidine 5'-diphosphate competitive inhibition, Ki: 0.0085 mM Glaesserella parasuis
GDP competitive inhibition, Ki: 0.0025 mM Glaesserella parasuis
N1-butylnicotinamide chloride competitive inhibition, Ki: 0.408 mM Glaesserella parasuis
N1-heptylnicotinamide chloride competitive inhibition, Ki: 0.48 mM Glaesserella parasuis
N1-hexylnicotinamide chloride competitive inhibition, Ki: 0.629 mM Glaesserella parasuis
N1-octylnicotinamide chloride competitive inhibition, Ki: 0.287 mM Glaesserella parasuis
N1-pentylnicotinamide chloride competitive inhibition, Ki: 0.297 mM Glaesserella parasuis
uridine 5'-diphosphate competitive inhibition, Ki: 0.0012 mM Glaesserella parasuis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
nicotinamide guanine dinucleotide
-
Glaesserella parasuis
0.004
-
NAD+ biphasic hydrolysis, functions in a manner indicative of negative cooperativity Glaesserella parasuis
0.005
-
NADP+
-
Glaesserella parasuis
0.015
-
FAD does not exhibit negative cooperativity Glaesserella parasuis
0.144
-
nicotinamide 1,N6-ethenoadenine dinucleotide does not exhibit negative cooperativity Glaesserella parasuis
0.351
-
coenzyme A does not exhibit negative cooperativity Glaesserella parasuis

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
-
Glaesserella parasuis
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
gel filtration Glaesserella parasuis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-ribose + H2O Glaesserella parasuis
-
AMP + phosphoribose
-
?
coenzyme A + H2O Glaesserella parasuis low activity ?
-
?
FAD + H2O Glaesserella parasuis
-
FMN + AMP
-
?
NAD+ + H2O Glaesserella parasuis
-
NMN + AMP
-
?
NADP+ + H2O Glaesserella parasuis
-
NMN + adenosine 2',5'-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Glaesserella parasuis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography techniques Glaesserella parasuis

Source Tissue

Source Tissue Comment Organism Textmining
cell culture potential growth inhibition by adenosine diphosphate Glaesserella parasuis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
13.5
-
-
Glaesserella parasuis

Storage Stability

Storage Stability Organism
-15°C, 0.1 M KCl, 6 months Glaesserella parasuis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,4-dihydronicotinamide adenine dinucleotide + H2O
-
Glaesserella parasuis 1,4-dihydronicotinamide mononucleotide + 5'-AMP
-
?
3-acetylpyridine adenine dinucleotide + H2O
-
Glaesserella parasuis 3-acetylpyridine riboside 5'-phosphate + 5'-AMP
-
?
3-aminopyridine adenine dinucleotide + H2O
-
Glaesserella parasuis 3-aminopyridine riboside 5'-phosphate + 5'-AMP
-
?
3-methylpyridine adenine dinucleotide + H2O
-
Glaesserella parasuis 3-methylpyridine mononucleotide + 5'-AMP
-
?
3-pyridylcarbinol adenine dinucleotide + H2O
-
Glaesserella parasuis ?
-
?
ADP-ribose + H2O
-
Glaesserella parasuis AMP + phosphoribose
-
?
coenzyme A + H2O low activity Glaesserella parasuis ?
-
?
FAD + H2O
-
Glaesserella parasuis FMN + AMP
-
?
GDP-glucose + H2O
-
Glaesserella parasuis GMP + D-glucose-1-phosphate
-
?
NAD+ + H2O
-
Glaesserella parasuis NMN + AMP
-
?
NADP+ + H2O
-
Glaesserella parasuis NMN + adenosine 2',5'-phosphate
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
-
Glaesserella parasuis NMN + N6-ethenoadenosine 5'-phosphate
-
?
nicotinamide guanine dinucleotide + H2O
-
Glaesserella parasuis NMN + GMP
-
?
nicotinamide hypoxanthine dinucleotide + H2O
-
Glaesserella parasuis NMN + hypoxanthine monophosphate
-
?
nicotinic acid adenine dinucleotide + H2O
-
Glaesserella parasuis nicotinic acid mononucleotide + 5'-AMP
-
?
pyridine adenine dinucleotide + H2O
-
Glaesserella parasuis pyridine riboside 5'-phosphate + 5'-AMP
-
?
thionicotinamide adenine dinucleotide + H2O
-
Glaesserella parasuis thionicotinamide mononucleotide + 5'-AMP
-
?
uridine diphosphoglucose + H2O
-
Glaesserella parasuis UMP + D-glucose-1-phosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 70000, SDS-PAGE Glaesserella parasuis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
below no thermal inactivation within 60 min Glaesserella parasuis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0012
-
uridine 5'-diphosphate competitive inhibition Glaesserella parasuis
0.0025
-
GDP competitive inhibition Glaesserella parasuis
0.0085
-
cytidine 5'-diphosphate competitive inhibition Glaesserella parasuis
0.287
-
N1-octylnicotinamide chloride competitive inhibition Glaesserella parasuis
0.297
-
N1-pentylnicotinamide chloride competitive inhibition Glaesserella parasuis
0.408
-
N1-butylnicotinamide chloride competitive inhibition Glaesserella parasuis
0.48
-
N1-heptylnicotinamide chloride competitive inhibition Glaesserella parasuis
0.629
-
N1-hexylnicotinamide chloride competitive inhibition Glaesserella parasuis