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Literature summary for 3.6.1.8 extracted from

  • Martins, S.M.; Torres, C.R.; Ferreira, S.T.
    Inhibition of the ecto-ATPdiphosphohydrolase of Schistosoma mansoni by thapsigargin (2000), Biosci. Rep., 20, 369-381.
    View publication on PubMed
Search for more literature for 3.6.1.8

Inhibitors

Inhibitors Comment Organism Structure
15-desoxybludein 0.065 mg/ml, 11% inhibition Schistosoma mansoni
eremantolide C 0.065 mg/ml, 17% inhibition Schistosoma mansoni
glaucolide A 0.065 mg/ml, 11% inhibition Schistosoma mansoni
glaucolide B 0.065 mg/ml, 16% inhibition Schistosoma mansoni
goyazensolide 0.065 mg/ml, 10% inhibition Schistosoma mansoni
isogoyazensolide 0.065 mg/ml, 11% inhibition Schistosoma mansoni
licnofolide 0.065 mg/ml, 22% inhibition Schistosoma mansoni
additional information no inhibition by 0.065 mg/ml 15-desoxygoyazensolide Schistosoma mansoni
thapsigargicin 0.065 mg/ml, 57% inhibition Schistosoma mansoni
thapsigargin inhibits ATP hydrolysis, 70% inhibition at 0.065 mg/ml, mixed type inhibition, little or not affected by changes in free Ca2+ or Mg2+ concentrations, hydrolysis of ADP is not inhibited Schistosoma mansoni

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0173
-
 ATP 37°C, pH 7.4 Schistosoma mansoni

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Schistosoma mansoni AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
ATPDase
-
 Schistosoma mansoni
ATPdiphosphohydrolase
-
 Schistosoma mansoni

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.02
-
 thapsigargin 37°C, pH 7.4, inhibition of ATP hydrolysis Schistosoma mansoni