Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.7 extracted from

  • Raijman, L.; Grisolia, S.; Edelhoch, H.
    Further purification and properties of brain acyl phosphatase (1960), J. Biol. Chem., 235, 2340-2342.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
inosinic acid brain enzyme, no effect up to 2.3 mM, 4.6 mM: 33% activation, further increase in concentration, does not produce further activation Bos taurus
papain brain enzyme, slight, 15%, activation Bos taurus

General Stability

General Stability Organism
brain enzyme, stable to proteolytic enzymes Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adrenaline brain enzyme, at high concentrations, 12.5 mM: 65% inhibition Bos taurus
dinitrophenol brain enzyme, 0.25 mM: 50% inhibition Bos taurus
guanidine brain enzyme, 5 M: 100% reversible inhibition, 95% of original activity is recovered upon lowering the guanidine concentration by dilution Bos taurus
additional information brain enzyme, no inhibition by caffeine, inosinic acid, 0.5% trypsin and 1% papain Bos taurus
Pepsin brain enzyme, 2%: inactivation Bos taurus
phosphate brain enzyme 20 mM: 50-60% inhibition, 40 mM: 70-80% inhibition Bos taurus
thyroxine brain enzyme, more inhibitory when preincubation is conducted at 16°C than at 25°C Bos taurus
Urea brain enzyme, 5 M: 100% reversible inhibition, 95% of original activity is recovered upon lowering the urea concentration by dilution Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13200
-
brain, ultracentrifugation Bos taurus

Organic Solvent Stability

Organic Solvent Comment Organism
Ethanol unstable to Bos taurus
Methanol unstable to Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-

Purification (Commentary)

Purification (Comment) Organism
brain Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2638
-
brain Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl phosphate + H2O
-
Bos taurus acetate + phosphate
-
?
acylphosphate + H2O specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates Bos taurus carboxylate + phosphate
-
?
carbamoyl phosphate + H2O
-
Bos taurus carbamate + phosphate
-
?

Subunits

Subunits Comment Organism
monomer brain enzyme, 1 * 13200, ultracentrifugation Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
assay at Bos taurus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
enzyme is thermostable Bos taurus
37
-
brain enzyme, purified and dialyzed enzyme, 20 min, 27% inactivation, undialyzed enzyme: no inactivation Bos taurus
80
-
brain enzyme, partially purified, 15 min, pH 1: 100% activity retained, pH 7: 80-90% activity retained Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Bos taurus

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
brain enzyme, stable over a wide pH range Bos taurus
1.5 8.2 brain enzyme, 24 h: no decrease of activity Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.25
-
dinitrophenol brain enzyme Bos taurus