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Literature summary for 3.6.1.6 extracted from

  • Kauffenstein, G.; Fuerstenau, C.R.; DOrleans-Juste, P.; Sevigny, J.
    The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation (2010), Br. J. Pharmacol., 159, 576-585.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of E-NTPDase1 knock-out mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Mus musculus
-
AMP + phosphate
-
?
ADP + H2O Mus musculus 129 SVJ x C57 BL/6
-
AMP + phosphate
-
?
ATP + 2 H2O Mus musculus
-
AMP + 2 phosphate
-
?
ATP + 2 H2O Mus musculus 129 SVJ x C57 BL/6
-
AMP + 2 phosphate
-
?
additional information Mus musculus the enzyme specifically binds to P2Y1 and P2Y2 receptors ?
-
?
additional information Mus musculus 129 SVJ x C57 BL/6 the enzyme specifically binds to P2Y1 and P2Y2 receptors ?
-
?
UTP + H2O Mus musculus
-
UDP + phosphate
-
?
UTP + H2O Mus musculus 129 SVJ x C57 BL/6
-
UDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus 129 SVJ x C57 BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adventitia NTPDase1 and NTPDase2 Mus musculus
-
aorta
-
Mus musculus
-
endothelial cell
-
Mus musculus
-
liver endothelium and hepatic central vein Mus musculus
-
vascular system
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
Mus musculus AMP + phosphate
-
?
ADP + H2O
-
Mus musculus 129 SVJ x C57 BL/6 AMP + phosphate
-
?
ATP + 2 H2O
-
Mus musculus AMP + 2 phosphate
-
?
ATP + 2 H2O
-
Mus musculus 129 SVJ x C57 BL/6 AMP + 2 phosphate
-
?
additional information the enzyme specifically binds to P2Y1 and P2Y2 receptors Mus musculus ?
-
?
additional information the enzyme specifically binds to P2Y1 and P2Y2 receptors Mus musculus 129 SVJ x C57 BL/6 ?
-
?
UTP + H2O
-
Mus musculus UDP + phosphate
-
?
UTP + H2O
-
Mus musculus 129 SVJ x C57 BL/6 UDP + phosphate
-
?

Synonyms

Synonyms Comment Organism
E-NTPDase1
-
Mus musculus
ecto-nucleotidase
-
Mus musculus
NTPDase1
-
Mus musculus
nucleoside triphosphate diphosphohydrolase-1
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

General Information

General Information Comment Organism
malfunction nucleotide hydrolysis is impaired in the wall of Entpd1-/- vessels compared with Entpd1+/+ aortas, which display significant ADPase and ATPase activity Mus musculus
additional information uracil nucleotides induce a strong contractile response in Entpd1-/- denuded aortic rings, ATP and ADP do not display constrictor effect at concentrations below 0.03 mM Mus musculus
physiological function NTPDase1 controls endothelial P2Y receptor-dependent relaxation, regulating both agonist level and P2 receptor reactivity. NTPDase1 differentially influences UTP and ATP responses in vivo Mus musculus