Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of E-NTPDase1 knock-out mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + H2O | Mus musculus | - |
AMP + phosphate | - |
? | |
ADP + H2O | Mus musculus 129 SVJ x C57 BL/6 | - |
AMP + phosphate | - |
? | |
ATP + 2 H2O | Mus musculus | - |
AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | Mus musculus 129 SVJ x C57 BL/6 | - |
AMP + 2 phosphate | - |
? | |
additional information | Mus musculus | the enzyme specifically binds to P2Y1 and P2Y2 receptors | ? | - |
? | |
additional information | Mus musculus 129 SVJ x C57 BL/6 | the enzyme specifically binds to P2Y1 and P2Y2 receptors | ? | - |
? | |
UTP + H2O | Mus musculus | - |
UDP + phosphate | - |
? | |
UTP + H2O | Mus musculus 129 SVJ x C57 BL/6 | - |
UDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus 129 SVJ x C57 BL/6 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adventitia | NTPDase1 and NTPDase2 | Mus musculus | - |
aorta | - |
Mus musculus | - |
endothelial cell | - |
Mus musculus | - |
liver | endothelium and hepatic central vein | Mus musculus | - |
vascular system | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + H2O | - |
Mus musculus | AMP + phosphate | - |
? | |
ADP + H2O | - |
Mus musculus 129 SVJ x C57 BL/6 | AMP + phosphate | - |
? | |
ATP + 2 H2O | - |
Mus musculus | AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | - |
Mus musculus 129 SVJ x C57 BL/6 | AMP + 2 phosphate | - |
? | |
additional information | the enzyme specifically binds to P2Y1 and P2Y2 receptors | Mus musculus | ? | - |
? | |
additional information | the enzyme specifically binds to P2Y1 and P2Y2 receptors | Mus musculus 129 SVJ x C57 BL/6 | ? | - |
? | |
UTP + H2O | - |
Mus musculus | UDP + phosphate | - |
? | |
UTP + H2O | - |
Mus musculus 129 SVJ x C57 BL/6 | UDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
E-NTPDase1 | - |
Mus musculus |
ecto-nucleotidase | - |
Mus musculus |
NTPDase1 | - |
Mus musculus |
nucleoside triphosphate diphosphohydrolase-1 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | nucleotide hydrolysis is impaired in the wall of Entpd1-/- vessels compared with Entpd1+/+ aortas, which display significant ADPase and ATPase activity | Mus musculus |
additional information | uracil nucleotides induce a strong contractile response in Entpd1-/- denuded aortic rings, ATP and ADP do not display constrictor effect at concentrations below 0.03 mM | Mus musculus |
physiological function | NTPDase1 controls endothelial P2Y receptor-dependent relaxation, regulating both agonist level and P2 receptor reactivity. NTPDase1 differentially influences UTP and ATP responses in vivo | Mus musculus |