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Literature summary for 3.6.1.59 extracted from

  • Kowalska, J.; Wypijewska del Nogal, A.; Darzynkiewicz, Z.M.; Buck, J.; Nicola, C.; Kuhn, A.N.; Lukaszewicz, M.; Zuberek, J.; Strenkowska, M.; Ziemniak, M.; Maciejczyk, M.; Bojarska, E.; Rhoads, R.E.; Darzynkiewicz, E.; Sahin, U.; Jemielity, J.
    Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes (2014), Nucleic Acids Res., 42, 10245-10264.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans G5EFS4
-
-
Homo sapiens Q96C86
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-dimethylguanosine 5'-[3-(5'-guanosinyl)-3-boranotriphosphate] + H2O boranophosphate analog of the mRNA cap. 90 Min reaction time, 11% cleavage of S-enantiomer, 98% cleavage of R-enantiomer Homo sapiens 7-methylguanosine 5'-phosphate + ?
-
?
7-dimethylguanosine 5'-[3-(5'-guanosinyl)-3-boranotriphosphate] + H2O boranophosphate analog of the mRNA cap. 90 Min reaction time, 6% cleavage of S-enantiomer, 97% cleavage of R-enantiomer Caenorhabditis elegans 7-methylguanosine 5'-phosphate + ?
-
?
7-methylguanosin-5'-yl-[3-(5'-guanosinyl)-2-boranotriphosphate] + H2O boranophosphate analog of the mRNA cap. 10 Min reaction time, 90-100% cleavage Caenorhabditis elegans 7-methylguanosine 5'-phosphate + ?
-
?
7-methylguanosin-5'-yl-[3-(5'-guanosinyl)-2-boranotriphosphate] + H2O boranophosphate analog of the mRNA cap. 90 Min reaction time, 12-19% cleavage Homo sapiens 7-methylguanosine 5'-phosphate + ?
-
?
m7G5'ppp5'G + H2O
-
Homo sapiens 7-methylguanosine 5'-phosphate + GDP
-
?
m7G5'ppp5'G + H2O
-
Caenorhabditis elegans 7-methylguanosine 5'-phosphate + GDP
-
?

Synonyms

Synonyms Comment Organism
Dcps
-
Homo sapiens
Dcps
-
Caenorhabditis elegans