Application | Comment | Organism |
---|---|---|
medicine | measurements of 8-oxo-dGTPase activity in brains, testes and kidneys may serve as a rough indicator rather than a quantifiable marker of radiation-induced oxidative stress | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxy-dATP + 2 H2O | Mus musculus | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively | 2-hydroxy-dAMP + 2 phosphate | - |
? | |
8-oxo-dGTP + H2O | Mus musculus | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | 8-oxo-dGMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers | Mus musculus | - |
kidney | a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers | Mus musculus | - |
testis | a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxy-dATP + 2 H2O | - |
Mus musculus | 2-hydroxy-dAMP + 2 phosphate | - |
? | |
2-hydroxy-dATP + 2 H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively | Mus musculus | 2-hydroxy-dAMP + 2 phosphate | - |
? | |
8-oxo-dGTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | Mus musculus | 8-oxo-dGMP + diphosphate | - |
? | |
8-oxo-dGTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | Mus musculus | 8-oxo-dGMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase | - |
Mus musculus |
MTH1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers | up |