Literature summary for 3.6.1.56 extracted from

Song, X.N.; Zhang, L.Q.; Liu, D.G.; Lin, J.; Zheng, J.D.; Dai, D.P.; Hei, A.L.; Hayakawa, H.; Sekiguchi, M.; Cai, J.P.
Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients (2011), Neurochem. Res., 36, 1558-1565.

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Application

Application	Comment	Organism
medicine	increased amounts of 8-oxoguanine in the RNA, and decreased expression of MTH1 are observed in the hippocampi of patients suffering from Alzheimer's disease	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-
Mus musculus SAMP8	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	age-related accumulation of 8-oxoguanine in RNA is correlated with decreased expression of MTH1	Mus musculus	-
hippocampus	increased amounts of 8-oxoguanine in the RNA, and decreased expression of MTH1 are observed in the hippocampi of patients suffering from Alzheimer's disease	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MTH1	-	Mus musculus
MTH1	-	Homo sapiens

Expression

Organism	Comment	Expression
Mus musculus	age-related accumulation of 8-oxoguanine in RNA is correlated with decreased expression of MTH1	down
Homo sapiens	increased amounts of 8-oxoguanine in the RNA, and decreased expression of MTH1 are observed in the hippocampi of patients suffering from Alzheimer's disease	down

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Release 2023.1 (January 2023)