Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P36639 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MTH1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the knockdown of the MTH1, MTH2, and NUDT5 proteins increases the A:T to C:G substitution mutations induced by 8-hydroxy-dGTP. In addition, the increase in the induced mutation frequency is more evident in the triple-knockdown cells | Homo sapiens |
physiological function | all three of the human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP | Homo sapiens |