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Literature summary for 3.6.1.56 extracted from

  • Cai, J.P.; Ishibashi, T.; Takagi, Y.; Hayakawa, H.; Sekiguchi, M.
    Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides (2003), Biochem. Biophys. Res. Commun., 305, 1073-1077.
    View publication on PubMed
Search for more literature for 3.6.1.56

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli. Expression of cDNA for mMTH2 reduces significantly the elevated level of spontaneous mutation frequency of Escherichia coli mutT(-) cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.032
-
 8-oxo-dGTP pH and temperature not specified in the publication Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Mus musculus 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP 8-oxo-dGMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BG93
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP Mus musculus 8-oxo-dGMP + diphosphate
-
 ?
8-oxo-dGTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. The MTH2 protein prevents mutations caused by 8-oxoguanine nucleotides. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP Mus musculus 8-oxo-dGMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
MTH2
-
 Mus musculus