Literature summary for 3.6.1.56 extracted from

Kajitani, K.; Yamaguchi, H.; Dan, Y.; Furuichi, M.; Kang, D.; Nakabeppu, Y.
MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity (2006), J. Neurosci., 26, 1688-1698.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	excitotoxicity initiated by kainate administration results in an increase ofMTH1protein expression in the mouse hippocampus	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	MTH1 efficiently suppresses the accumulation of 8-oxoguanine in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity (caused by the systemic administration of kainate)	Mus musculus

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Release 2023.1 (January 2023)