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Literature summary for 3.6.1.55 extracted from

  • Yin, Y.; Sasaki, S.; Taniguchi, Y.
    Inhibitory effect of 8-halogenated 7-deaza-2-deoxyguanosine triphosphates on human 8-oxo-2'-deoxyguanosine triphosphatase, hMTH1, activities (2016), ChemBioChem, 17, 566-569 .
    View publication on PubMed
Search for more literature for 3.6.1.55

Inhibitors

Inhibitors Comment Organism Structure
(S)-crizotinib
-
 Homo sapiens
2-hydroxy-dADP inhibitory at low-micromolar concentrations Homo sapiens
2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol i.e. SCH51344 Homo sapiens
6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine i.e. TH287, strongest inhibitor Homo sapiens
7-deaza-dGTP
-
 Homo sapiens
7-iodo-7-deaza-dGTP
-
 Homo sapiens
8-bromo-7-deaza-dGTP
-
 Homo sapiens
8-bromo-dGTP
-
 Homo sapiens
8-chloro-7-deaza-dGTP
-
 Homo sapiens
8-iodo-7-deaza-2'-deoxyguanosine
-
 Homo sapiens
8-iodo-7-deaza-dGTP
-
 Homo sapiens
8-oxo-dGDP inhibitory at low-micromolar concentrations Homo sapiens
dGTP
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 8-oxo-dGTP at pH 7.5 and 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 4 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Homo sapiens
-
 8-oxo-dGMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O
-
 Homo sapiens 8-oxo-dGMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
8-oxo-2'-deoxyguanosine triphosphatase
-
 Homo sapiens
8-oxo-dG triphosphatase
-
 Homo sapiens
MTH1
-
 Homo sapiens
NUDT1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
18.9
-
 8-oxo-dGTP at pH 7.5 and 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000028
-
 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine at pH 7.5 and 37°C Homo sapiens
0.0000617
-
 8-bromo-7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens
0.000117
-
 8-chloro-7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens
0.000203
-
 (S)-crizotinib at pH 7.5 and 37°C Homo sapiens
0.000213
-
 7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens
0.00065
-
 7-iodo-7-deaza-dGTP at pH 7.5 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 at pH 7.5 and 37°C Homo sapiens 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
0.00042
-
 at pH 7.5 and 37°C Homo sapiens 8-iodo-7-deaza-dGTP
0.0005
-
 at pH 7.5 and 37°C Homo sapiens 8-bromo-7-deaza-dGTP
0.00086
-
 at pH 7.5 and 37°C Homo sapiens 8-chloro-7-deaza-dGTP
0.001
-
 at pH 7.5 and 37°C Homo sapiens (S)-crizotinib
0.00157
-
 at pH 7.5 and 37°C Homo sapiens 7-deaza-dGTP
0.00223
-
 at pH 7.5 and 37°C Homo sapiens 2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
0.00262
-
 at pH 7.5 and 37°C Homo sapiens 7-iodo-7-deaza-dGTP
0.01675
-
 at pH 7.5 and 37°C Homo sapiens 8-bromo-dGTP
0.0448
-
 at pH 7.5 and 37°C Homo sapiens 8-iodo-7-deaza-2'-deoxyguanosine
1.998
-
 at pH 7.5 and 37°C Homo sapiens dGTP