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Literature summary for 3.6.1.55 extracted from

  • Saraswat, V.; Massiah, M.A.; Lopez, G.; Amzel, L.M.; Mildvan, A.S.
    Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase (2002), Biochemistry, 41, 15566-15577.
    View publication on PubMed
Search for more literature for 3.6.1.55

Inhibitors

Inhibitors Comment Organism Structure
8-oxo-dGMP noncompetitive inhibitor of dGTP hydrolysis Escherichia coli
dGMP noncompetitive inhibitor of dGTP hydrolysis Escherichia coli
diphosphate linear uncompetitive inhibitor of dGTP hydrolysis Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Escherichia coli
Mn2+ activates Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Escherichia coli
-
 8-oxo-dGMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O
-
 Escherichia coli 8-oxo-dGMP + diphosphate
-
 ?
8-oxo-dGTP + H2O the unusually high affinity of MutT for 8-oxo-nucleotides is due not only to interactions with the altered 8-oxo or 7-NH positions on guanine, but results primarily from diffuse structural changes which tighten the protein structure around the 8-oxo-nucleotide Escherichia coli 8-oxo-dGMP + diphosphate
-
 ?
dGTP + H2O
-
 Escherichia coli dGMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
MutT
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000049
-
 8-oxo-dGMP pH 7.5, 23°C, Mg2+-activated, Ki(slope) Escherichia coli
0.000173
-
 8-oxo-dGMP pH 7.5, 23°C, Mn2+-activated, Ki(slope) Escherichia coli
0.000593
-
 8-oxo-dGMP pH 7.5, 23°C, Mn2+-activated, Ki(intercept) Escherichia coli
0.00162
-
 8-oxo-dGMP pH 7.5, 23°C, Mg2+-activated, Ki(intercept) Escherichia coli
0.413
-
 diphosphate pH 7.5, 23°C, Mn2+-activated, Ki(intercept) Escherichia coli
1.74
-
 dGMP pH 7.5, 23°C, Mg2+-activated, Ki(slope) Escherichia coli
3.96
-
 dGMP pH 7.5, 23°C, Mn2+-activated, Ki(slope) Escherichia coli
4.57
-
 dGMP pH 7.5, 23°C, Mn2+-activated, Ki(intercept) Escherichia coli
4.95
-
 diphosphate pH 7.5, 23°C, Mg2+-activated, Ki(intercept) Escherichia coli
14.5
-
 dGMP pH 7.5, 23°C, Mg2+-activated, Ki(intercept) Escherichia coli