BRENDA - Enzyme Database show
show all sequences of 3.6.1.52

Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues

Wu, M.; Chong, L.S.; Capolicchio, S.; Jessen, H.J.; Resnick, A.C.; Fiedler, D.; Angew. Chem. Int. Ed. Engl. 53, 7192-7197 (2014)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,4,5,6-pentaphosphate
competitive
Homo sapiens
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
competitive
Homo sapiens
inositol 4-butyl-1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
competitive
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O95989
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
diphosphoinositol polyphosphate + H2O
-
733091
Homo sapiens
inositol polyphosphate + phosphate
-
-
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O
-
733091
Homo sapiens
AMP + adenosine 5'-tetraphosphate
reaction of EC 3.6.1.17
-
-
?
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000023
-
inositol 4-butyl-1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
0.00011
-
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,4,5,6-pentaphosphate
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
0.00027
-
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,4,5,6-pentaphosphate
competitive
Homo sapiens
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
competitive
Homo sapiens
inositol 4-butyl-1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
competitive
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000023
-
inositol 4-butyl-1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
0.00011
-
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,4,5,6-pentaphosphate
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
0.00027
-
inositol 1-[(phosphorylmethyl)phosphonic acid]-2,3,5,6-tetraphosphate
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
diphosphoinositol polyphosphate + H2O
-
733091
Homo sapiens
inositol polyphosphate + phosphate
-
-
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O
-
733091
Homo sapiens
AMP + adenosine 5'-tetraphosphate
reaction of EC 3.6.1.17
-
-
?
Other publictions for EC 3.6.1.52
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733091
Wu
Elucidating diphosphoinositol ...
Homo sapiens
Angew. Chem. Int. Ed. Engl.
53
7192-7197
2014
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3
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3
3
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2
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719961
Lonetti
Identification of an evolution ...
Homo sapiens
J. Biol. Chem.
286
31966-31974
2011
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5
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1
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1
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712171
Winward
Oxidation of the diphosphoinos ...
Drosophila melanogaster
Int. J. Biochem. Cell Biol.
42
1174-1181
2010
-
-
1
-
-
-
-
5
2
4
-
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1
2
1
-
1
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4
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22
-
1
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-
5
1
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-
1
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-
-
-
-
-
5
2
4
-
-
1
1
-
1
-
4
-
-
22
-
1
-
-
5
1
-
-
-
1
-
-
1
5
5
668226
Chu
Ectopic expression of murine d ...
Mus musculus
Cell. Signal.
16
1045-1059
2004
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1
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1
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1
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3
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1
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7
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1
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1
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1
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1
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1
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7
-
-
1
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657829
Hua
Paralogous murine Nudt10 and N ...
Mus musculus
Biochem. J.
373
81-89
2003
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-
1
-
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-
-
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2
1
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5
-
1
1
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1
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5
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1
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2
1
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1
1
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1
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5
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-
659184
Hidaka
An adjacent pair of human NUDT ...
Homo sapiens
J. Biol. Chem.
277
32730-32738
2002
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-
1
-
1
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1
-
1
2
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3
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1
1
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-
2
-
-
8
-
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2
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1
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1
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2
2
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2
2
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3
-
-
8
-
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-
659817
Cartwright
The g5R (D250) gene of African ...
African swine fever virus
J. Virol.
76
1415-1421
2002
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-
1
-
-
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1
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2
1
1
-
2
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1
1
-
-
1
-
-
1
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-
-
-
-
1
-
1
-
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1
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-
-
1
-
2
1
1
-
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1
1
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1
-
-
1
-
-
-
-
-
1
-
1
-
-
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-
-
-
-
393827
Caffrey
Discovery of molecular and cat ...
Homo sapiens
J. Biol. Chem.
275
12730-12736
2000
-
-
1
-
-
-
-
2
-
-
1
-
-
4
-
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-
-
-
-
-
-
1
1
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-
3
-
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1
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-
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2
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1
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-
1
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
393825
Safrany
The diadenosine hexaphosphate ...
Homo sapiens
J. Biol. Chem.
274
21735-21740
1999
-
-
-
-
-
-
-
2
-
-
-
-
-
5
-
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-
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3
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4
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2
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3
-
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4
-
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-
-
-
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-
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-
-
393826
Yang
Site-directed mutagenesis of d ...
Homo sapiens
J. Biol. Chem.
274
35434-35440
1999
-
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-
-
10
-
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2
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3
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10
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3
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393824
Safrany
A novel context for the 'MutT' ...
Homo sapiens, Rattus norvegicus
EMBO J.
17
6599-6607
1998
-
-
1
-
2
-
2
2
-
1
3
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4
-
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1
-
-
2
1
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8
1
-
-
-
-
2
1
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-
2
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1
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2
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2
2
2
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1
3
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1
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2
1
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8
1
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2
1
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