Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ARL 67156 | knocking down NTPDase2 expression using siRNA or inhibiting NTPDases activity with ARL 67156 simultaneously reduces ATP hydrolysis and ADP formation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y5L3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | HaCaT keratinocyte | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Homo sapiens | ADP + phosphate | in the presence of NTPDase2, extracellular ATP is hydrolyzed and converted into ADP. Knocking down NTPDase2 expression using siRNA or inhibiting NTPDases activity with ARL 67156 simultaneously reduces ATP hydrolysis and ADP formation. The amount of generated ADP is proportional to the amount of ATP hydrolyzed in all treatments | ? |
Synonyms | Comment | Organism |
---|---|---|
ENTPD2 | - |
Homo sapiens |
NTPDase2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | pharmacological inhibition by ARL 67156 or gene silencing of the endogenous ecto-nucleoside triphosphate diphosphohydrolase isoform 2 results in a 25% reduction in both ATP hydrolysis and ADP formation. NTPDase2 hydrolyzes ATP and generates sustainable ADP levels. Knocking down NTPDase2 potentiates the nanomolar ATP-induced intracellular calcium increase | Homo sapiens |