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Literature summary for 3.6.1.5 extracted from

  • Haller, C.A.; Cui, W.; Wen, J.; Robson, S.C.; Chaikof, E.L.
    Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory properties (2006), J. Vasc. Surg., 43, 816-823.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme in lipid vesicles effectively inhibits platelet aggregation when activated by ADP, collagen, or thrombin, and also promotes platelet disaggregation. Treatment with enzyme lipid vesicles preserves platelet counts after thromboplastin injection Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme
-

Purification (Commentary)

Purification (Comment) Organism
reconstitution of enzyme in lipid vesicles is associated with a decrease in KM value of nearly an order of magnitude over the detergent-solubilized form, with a concomitant increase in both ADPase and ATPase catalytic efficiencies Homo sapiens