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Literature summary for 3.6.1.5 extracted from

  • Demenis, M.A.; Furriel, R.P.M.; Leone, F.A.
    Characterization of an ectonucleoside triphosphate diphosphohydrolase 1 activity in alkaline phosphatase-depleted rat osseous plate membranes: possible functional involvement in the calcification process (2003), Biochim. Biophys. Acta, 1646, 216-225.
    View publication on PubMed
Search for more literature for 3.6.1.5

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: oligomycin, ouabain, bafilomycin A, theophylline, thapsigarin, ethacrynic acid, P1,P5-(adenosine-5’)pentyphosphate, omeprazole Rattus norvegicus
Sodium azide
-
 Rattus norvegicus
suramin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.083
-
 ATP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.085
-
 ATP pH 7.5, 37°C, presence of Ca2+ Rattus norvegicus
0.148
-
 CTP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.15
-
 ADP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.164
-
 GTP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.196
-
 ADP pH 7.5, 37°C, presence of Ca2+ Rattus norvegicus
0.207
-
 UTP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.259
-
 ITP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.357
-
 GDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.555
-
 UDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.622
-
 IDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus
0.777
-
 CDP pH 7.5, 37°C, presence of Mg2+ Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ or Mg2+, required, Km-value 0.377 mM Rattus norvegicus
Mg2+ or Ca2+, required, Km-value 0.595 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osseous plate alkaline phosphatase depleted Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Rattus norvegicus AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Rattus norvegicus AMP + 2 phosphate
-
 ?
CDP + H2O
-
 Rattus norvegicus CMP + phosphate
-
 ?
CTP + 2 H2O
-
 Rattus norvegicus CMP + 2 phosphate
-
 ?
GDP + H2O
-
 Rattus norvegicus GMP + phosphate
-
 ?
GTP + 2 H2O
-
 Rattus norvegicus GMP + 2 phosphate
-
 ?
IDP + H2O
-
 Rattus norvegicus IMP + phosphate
-
 ?
ITP + 2 H2O
-
 Rattus norvegicus IMP + 2 phosphate
-
 ?
UDP + H2O
-
 Rattus norvegicus UMP + phosphate
-
 ?
UTP + 2 H2O
-
 Rattus norvegicus UMP + 2 phosphate
-
 ?