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Literature summary for 3.6.1.44 extracted from

  • Massarweh, A.; Bosco, M.; Iatmanen-Harbi, S.; Tessier, C.; Auberger, N.; Busca, P.; Chantret, I.; Gravier-Pelletier, C.; Moore, S.E.
    Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle (2016), J. Lipid Res., 57, 1029-1042 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.44

Inhibitors

Inhibitors Comment Organism Structure
citronellyl diphosphate
-
 Homo sapiens
farnesyl diphosphate
-
 Homo sapiens
geranyl diphosphate
-
 Homo sapiens
geranylgeranyl diphosphate
-
 Homo sapiens
GlcNAc-diphosphosolanesol
-
 Homo sapiens
GlcNAc2-diphosphosolanesol
-
 Homo sapiens
Hg2+
-
 Homo sapiens
isopentenyl diphosphate
-
 Homo sapiens
additional information not inhibited by NaF and EDTA Homo sapiens
solanesol
-
 Homo sapiens
solanesyl diphosphate
-
 Homo sapiens
solanesyl phosphate
-
 Homo sapiens
vanadate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ dependent on, 1 mM used in assay conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glc2Man5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc2Man5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
Glc2Man9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc2Man9GlcNAc2-phosphate + dolichyl phosphate
-
 ?
Glc3Man5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc3Man5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
Glc3Man9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Glc3Man9GlcNAc2-phosphate + dolichyl phosphate
-
 ?
GlcMan5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens GlcMan5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
GlcMan9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens GlcMan9GlcNAc2-phosphate + dolichyl phosphate
-
 ?
GlcNAc2-PP-solanesol + H2O
-
 Homo sapiens GlcNAc2-phosphate + solanesyl phosphate
-
 ?
Man5GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Man5GlcNAc2-phosphate + dolichyl phosphate
-
 ?
Man7GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Man7GlcNAc2 phosphate + dolichyl phosphate
-
 ?
Man9GlcNAc2-diphosphodolichol + H2O
-
 Homo sapiens Man9GlcNAc2-phosphate + dolichyl phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DLO diphosphatase
-
 Homo sapiens
DLODP
-
 Homo sapiens
oligosaccharide-diphosphodolichol diphosphatase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 at pH 5.5 and 37°C Homo sapiens GlcNAc2-diphosphosolanesol
0.0012
-
 at pH 5.5 and 37°C Homo sapiens GlcNAc-diphosphosolanesol
0.0047
-
 at pH 5.5 and 37°C Homo sapiens solanesyl diphosphate
0.0078
-
 at pH 5.5 and 37°C Homo sapiens solanesyl phosphate
0.033
-
 at pH 5.5 and 37°C Homo sapiens solanesol