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Literature summary for 3.6.1.39 extracted from
- Purification and characterization of two different thymidine-5'-triphosphate-hydrolysing enzymes in human serum (1992), Biol. Chem. Hoppe-Seyler, 373, 237-247.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AgCl | Ki: 4 mM | Homo sapiens |  |
| EDTA | with 0.2-2.0 mM EDTA 80% loss of activity | Homo sapiens | |
| HgCl2 | Ki: 0.6 mM | Homo sapiens | |
| NaVO4 | Ki: 0.8 mM | Homo sapiens | |
| Tartrate | Ki: 1.5 mM | Homo sapiens | |
| Zn2+ | complete inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.038 | - |
dTTP | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
| Mg2+ | - |
Homo sapiens | |
| Mn2+ | best activator | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 23000 | - |
2 * 23000, SDS-PAGE | Homo sapiens |
| 46000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dTTP + H2O | Homo sapiens | - |
dTDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purified to homogenity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dCTP + H2O | very poor substrate | Homo sapiens | dCDP + phosphate | - |
? | |
| dTTP + H2O | - |
Homo sapiens | dTDP + phosphate | - |
? | |
| dUTP + H2O | - |
Homo sapiens | dUDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 23000, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 11 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.6 | - |
HgCl2 | - |
Homo sapiens | |
| 0.8 | - |
NaVO4 | - |
Homo sapiens | |
| 1.5 | - |
Tartrate | - |
Homo sapiens | |
| 4 | - |
AgCl | - |
Homo sapiens | |
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