Literature summary for 3.6.1.31 extracted from

Smith, D.W.E.; Ames, B.N.
Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis (1965), J. Biol. Chem., 240, 3056-3063.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EDTA	-	Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.022	-	N-1-(5'-phosphoribosyl)-ATP	-	Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required, optimum concentration 0.03 M	Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
43000	-	sucrose density gradient centrifugation	Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-1-(5'-phosphoribosyl)-ATP + H2O	Salmonella enterica subsp. enterica serovar Typhimurium	enzyme of histidine biosynthesis pathway	N-1-(5'-phosphoribosyl)-AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.003	-	-	Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-1-(5'-phosphoribosyl)-ATP + H2O	-	Salmonella enterica subsp. enterica serovar Typhimurium	N-1-(5'-phosphoribosyl)-AMP + diphosphate	-	ir
N-1-(5'-phosphoribosyl)-ATP + H2O	enzyme of histidine biosynthesis pathway	Salmonella enterica subsp. enterica serovar Typhimurium	N-1-(5'-phosphoribosyl)-AMP + diphosphate	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9	-	-	Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

pH Minimum	pH Maximum	Comment	Organism
7	10	75% of maximum activity at pH 7, 79% of maximum activity at pH 10	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)