Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyl dicarbonate | inactivation | Homo sapiens | |
suramin | strong, competitive inhibition, IC50: 0.002 mM | Homo sapiens | |
Zn2+ | IC50: 0.02 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0014 | - |
P1,P3-bis(5'-adenosyl)triphosphate | pH 7.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | maximal activation at 0.5-1.0 mM | Homo sapiens | |
Mg2+ | dependent on, maximal activation at 0.5-1.0 mM | Homo sapiens | |
Mn2+ | maximal activation at 0.5-1.0 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
17000 | - |
2 * 17000 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
P1,P3-bis(5'-adenosyl)triphosphate + H2O | Homo sapiens | - |
ADP + AMP | - |
? | |
P1,P3-bis(5'-adenosyl)triphosphate + H2O | Rattus norvegicus | - |
ADP + AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Purification (Comment) | Organism |
---|---|
native enzyme from blood platelets and leukocytes, 19000fold, by anion exchange chromatography and N6-5'-AMP affinity chromatography to homogeneity | Homo sapiens |
native enzyme from brain cytosolic fraction by ammonium sulfate fractionation, anion exchange chromatography, gel filtration, and N6-5'-AMP affinity chromatography to homogeneity | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
leukocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.34 | - |
purified native enzyme from leukocytes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
P1,P3-bis(5'-adenosyl)triphosphate + H2O | - |
Homo sapiens | ADP + AMP | - |
? | |
P1,P3-bis(5'-adenosyl)triphosphate + H2O | - |
Rattus norvegicus | ADP + AMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 17000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
diadenosine triphosphatase | - |
Homo sapiens |
diadenosine triphosphatase | - |
Rattus norvegicus |
tumour suppressor Fhit protein | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000022 | - |
suramin | pH 7.0, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
strong, competitive inhibition, IC50: 0.002 mM | Homo sapiens | suramin | |
0.02 | - |
IC50: 0.02 mM | Homo sapiens | Zn2+ |