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Literature summary for 3.6.1.29 extracted from

  • Asensio, A.C.; Rodriguez-Ferrer, C.R.; Oaknin, S.; Rotllan, P.
    Biochemical and immunochemical characterisation of human diadenosine triphosphatase provides evidence for its identification with the tumour suppressor Fhit protein (2006), Biochimie, 88, 461-471.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
diethyl dicarbonate inactivation Homo sapiens
suramin strong, competitive inhibition, IC50: 0.002 mM Homo sapiens
Zn2+ IC50: 0.02 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
P1,P3-bis(5'-adenosyl)triphosphate pH 7.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ maximal activation at 0.5-1.0 mM Homo sapiens
Mg2+ dependent on, maximal activation at 0.5-1.0 mM Homo sapiens
Mn2+ maximal activation at 0.5-1.0 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17000
-
2 * 17000 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
P1,P3-bis(5'-adenosyl)triphosphate + H2O Homo sapiens
-
ADP + AMP
-
?
P1,P3-bis(5'-adenosyl)triphosphate + H2O Rattus norvegicus
-
ADP + AMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
Sprague-Dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from blood platelets and leukocytes, 19000fold, by anion exchange chromatography and N6-5'-AMP affinity chromatography to homogeneity Homo sapiens
native enzyme from brain cytosolic fraction by ammonium sulfate fractionation, anion exchange chromatography, gel filtration, and N6-5'-AMP affinity chromatography to homogeneity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
leukocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.34
-
purified native enzyme from leukocytes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
P1,P3-bis(5'-adenosyl)triphosphate + H2O
-
Homo sapiens ADP + AMP
-
?
P1,P3-bis(5'-adenosyl)triphosphate + H2O
-
Rattus norvegicus ADP + AMP
-
?

Subunits

Subunits Comment Organism
dimer 2 * 17000 Homo sapiens

Synonyms

Synonyms Comment Organism
diadenosine triphosphatase
-
Homo sapiens
diadenosine triphosphatase
-
Rattus norvegicus
tumour suppressor Fhit protein
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.2
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000022
-
suramin pH 7.0, 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
strong, competitive inhibition, IC50: 0.002 mM Homo sapiens suramin
0.02
-
IC50: 0.02 mM Homo sapiens Zn2+