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Literature summary for 3.6.1.28 extracted from

  • Kovacevic, Z.; Fu, D.; Richardson, D.R.
    The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets (2008), Biochim. Biophys. Acta, 1783, 1981-1992.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information overexpression of N-myc downstream regulated gene-1, Ndrg-1, leads to upregulation of Thtpa in cancer cells, overview Homo sapiens
additional information overexpression of N-myc downstream regulated gene-1, Ndrg-1, leads to upregulation of Thtpa in cancer cells, overview Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens
expression analysis Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of N-myc downstream regulated gene-1, Ndrg-1, leads to upregulation of Thtpa in cancer cells, overview Homo sapiens
additional information overexpression of N-myc downstream regulated gene-1, Ndrg-1, leads to upregulation of Thtpa in cancer cells, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate ?
-
?
additional information Rattus norvegicus Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus Q8CGV7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AT6.1 cell metastatic prostate cancer cells Rattus norvegicus
-
DLD-1 cell non-metastatic human colorectal adenocarcinoma cells Homo sapiens
-
NCI-H1299 cell metastatic lung cancer cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate Homo sapiens ?
-
?
additional information Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate Rattus norvegicus ?
-
?
thiamine triphosphate + H2O
-
Homo sapiens thiamine diphosphate + phosphate
-
?
thiamine triphosphate + H2O
-
Rattus norvegicus thiamine diphosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
thiamine triphosphatase
-
Homo sapiens
thiamine triphosphatase
-
Rattus norvegicus
Thtpa
-
Homo sapiens
Thtpa
-
Rattus norvegicus