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Literature summary for 3.6.1.28 extracted from

  • Czerniecki, J.; Chanas, G.; Verlaet, M.; Bettendorff, L.; Makarchikov, A.F.; Leprince, P.; Wins, P.; Grisar, T.; Lakaye, B.
    Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain (2004), Neuroscience, 125, 833-840.
    View publication on PubMed
Search for more literature for 3.6.1.28

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm of neuronal perkarya Rattus norvegicus 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thiamine triphosphate + H2O Rattus norvegicus the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency thiamine diphosphate + phosphate
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain highest activity in hippocampal pyramidal neurons, as well as cerbellar granule cells and Purkinje cells. Some interneurons are also labeled and many thiamine triphosphatase mRNA-positive and immunoreactive cells are distributed thoughout cerebral cortical gray matter and the thalamus. No significant activity in white matter Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thiamine triphosphate + H2O
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 Rattus norvegicus thiamine diphosphate + phosphate
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thiamine triphosphate + H2O the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency Rattus norvegicus thiamine diphosphate + phosphate
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 ?

Synonyms

Synonyms Comment Organism
ThTPase
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 Rattus norvegicus