Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.28 extracted from

  • Iwata, H.; Baba, A.; Matsuda, T.
    Role of thiamine metabolism in the central nervous system. I. Basic properties of thiamine triphosphatase in rat brain (1974), Jpn. J. Pharmacol., 24, 817-823.
    View publication on PubMed
Search for more literature for 3.6.1.28

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ physiological concentrations markedly inhibit soluble TTPase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
microsome
-
 Rattus norvegicus
-
-
soluble
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ divalent cation requirement is fullfilled by Mg2+ or Ca2+ in microsomes and by Mg2+ but not Ca2+ in soluble fraction Rattus norvegicus
Mg2+ divalent cation requirement is fullfilled by Mg2+ or Ca2+ in microsomes and by Mg2+ but not Ca2+ in soluble fraction Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O 4% of the activity with thiamine triphosphate Rattus norvegicus ADP + phosphate
-
 ?
GTP + H2O at 13% of the activity with thiamine triphosphate Rattus norvegicus GDP + phosphate
-
 ?
thiamine triphosphate + H2O
-
 Rattus norvegicus thiamine diphosphate + phosphate
-
 ?
UTP + H2O no activity Rattus norvegicus UDP + phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 and a second optimum at pH 7.8, microsomal enzyme Rattus norvegicus
7.8
-
 and a second optimum at pH 6.5, microsomal enzyme Rattus norvegicus
8.5 9 soluble enzyme Rattus norvegicus