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Literature summary for 3.6.1.23 extracted from

  • Kumar, H.; Kehrer, J.; Singer, M.; Reinig, M.; Santos, J.M.; Mair, G.R.; Frischknecht, F.
    Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable (2019), Expert Opin. Ther. Targets, 23, 251-261 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Plasmodium berghei
-
 dUMP + diphosphate
-
 ?
dUTP + H2O Plasmodium berghei ANKA
-
 dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium berghei A0A509AI86
-
-
Plasmodium berghei ANKA A0A509AI86
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Plasmodium berghei dUMP + diphosphate
-
 ?
dUTP + H2O
-
 Plasmodium berghei ANKA dUMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
deoxyuridine triphosphate pyrophosphatase
-
 Plasmodium berghei
dUTPase
-
 Plasmodium berghei

General Information

General Information Comment Organism
malfunction enzyme null mutants are not viable Plasmodium berghei